# Purified Cortrophin® Gel (repository corticotropin injection USP) — Healthcare Professional Site > Purified Cortrophin® Gel (repository corticotropin injection USP) is a prescription injectable corticotropin manufactured by ANI Pharmaceuticals, Inc. This site is intended for US healthcare professionals only. It provides clinical information on all approved indications, proposed mechanism of action, dosing and administration, prescribing and enrollment resources, reimbursement and patient access support, and downloadable clinical materials including enrollment forms, patient brochures, billing and coding guides, and MAC flashcards. Cortrophin Gel is available as a multi-dose vial and single-dose prefilled syringe (PFS). Purified Cortrophin® Gel is a highly purified, natural-sequence ACTH (adrenocorticotropic hormone) product indicated across multiple therapeutic areas. It is the only FDA-approved purified ACTH therapy. The Cortrophin In Your Corner (CIYC) program provides patient access support including benefits investigation, prior authorization assistance, copay support, and specialty pharmacy coordination. Manufacturer: ANI Pharmaceuticals, Inc. HCP Website: https://www.cortrophinhcp.com Patient/Caregiver Website: https://www.cortrophin.com Prescribing Information: https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-prescribing-information.pdf Medical Information: 1-800-434-1121 Adverse Event Reporting: 1-800-308-6755 or www.fda.gov/medwatch Job Code: US-CG-2400054 04/2026 ## Pages - [Homepage](https://www.cortrophinhcp.com/): Overview of all approved indications for Cortrophin Gel for healthcare professionals, with links to condition-specific clinical information, proposed MOA, dosing, prescribe and enroll, reimbursement support, and resources. - [Proposed MOA of ACTH](https://www.cortrophinhcp.com/proposed-moa-of-acth): Interactive exploration of the proposed adrenal-dependent and proposed adrenal-independent mechanisms of action of ACTH. ACTH may possess both steroid-dependent and steroid-independent activity. Natural-sequence ACTH (1-39) may interact with MC1R, MC3R, MC4R, and MC5R receptors expressed on immune and inflammatory cells across multiple disease states. - [Cortrophin Gel & Dosing](https://www.cortrophinhcp.com/about-cortrophin-gel-and-dosing): Dosing guidelines, storage requirements, and administration instructions for Purified Cortrophin® Gel. Available as multi-dose vial and single-dose prefilled syringe. Storage: refrigerate at 36–46°F (2–8°C). Available in both subcutaneous and intramuscular presentations. - [Prescribe & Enroll](https://www.cortrophinhcp.com/prescribe-and-enroll): Step-by-step prescribing and enrollment guide for HCPs including enrollment forms, prior authorization support, and Cortrophin In Your Corner patient access program. - [Reimbursement & Support](https://www.cortrophinhcp.com/reimbursement-support): Coverage, reimbursement, and patient access support through Cortrophin In Your Corner including benefits investigation, prior authorization assistance, copay assistance (as little as $0/fill for eligible commercially insured patients), and patient assistance for uninsured patients. - [Resources](https://www.cortrophinhcp.com/resources): Downloadable clinical tools for HCPs including prescribing information, dosing guide, enrollment forms, injection guides, patient brochures by condition (English and Spanish), billing and coding guides, MAC flashcards, and office staff resources. ## Conditions - [Rheumatoid Arthritis (RA) Flares](https://www.cortrophinhcp.com/rheumatoid-arthritis-flares): Indicated for short-term administration as adjunctive therapy during an acute episode or exacerbation in rheumatoid arthritis, including juvenile rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and acute gouty arthritis. - [Acute Gouty Arthritis Flares](https://www.cortrophinhcp.com/acute-gouty-arthritis-flares): Indicated for short-term administration as adjunctive therapy during an acute episode or exacerbation in acute gouty arthritis. - [Atopic Dermatitis](https://www.cortrophinhcp.com/atopic-dermatitis): Indicated for treatment of atopic dermatitis (eczema) and serum sickness. - [Severe Psoriasis](https://www.cortrophinhcp.com/severe-psoriasis): Indicated for treatment of severe erythema multiforme (Stevens-Johnson syndrome) and severe psoriasis. - [Select Cases of SLE](https://www.cortrophinhcp.com/select-cases-of-sle): Indicated for exacerbations or as maintenance therapy in select cases of systemic lupus erythematosus. - [Select Cases of DM-PM](https://www.cortrophinhcp.com/select-cases-of-dm-pm): Indicated for exacerbations or as maintenance therapy in select cases of systemic dermatomyositis (polymyositis). - [Symptomatic Sarcoidosis](https://www.cortrophinhcp.com/symptomatic-sarcoidosis): Indicated for symptomatic sarcoidosis. - [Multiple Sclerosis Flares](https://www.cortrophinhcp.com/multiple-sclerosis-flares): Indicated for acute exacerbations of multiple sclerosis in adults. - [Proteinuria — FSGS](https://www.cortrophinhcp.com/proteinuria-due-to-certain-types-of-ns-fsgs): Indicated to induce diuresis or remission of proteinuria in nephrotic syndrome without uremia — focal segmental glomerulosclerosis (FSGS) patient information. - [Proteinuria — MN](https://www.cortrophinhcp.com/proteinuria-due-to-certain-types-of-ns-mn): Indicated to induce diuresis or remission of proteinuria in nephrotic syndrome without uremia — membranous nephropathy (MN) patient information. - [Severe Inflammatory Ophthalmic Diseases](https://www.cortrophinhcp.com/severe-inflammatory-ophthalmic-diseases): Indicated for severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa including keratitis, iritis, iridocyclitis, diffuse posterior uveitis and choroiditis, optic neuritis, chorioretinitis, and anterior segment inflammation. ## Optional - [Full Content Reference (llms-full.txt)](https://www.cortrophinhcp.com/llms-full.txt): Complete HCP clinical reference including full indications verbatim from label, proposed MOA detail, dosing table, full ISI, enrollment and reimbursement program details, and all PDF resource URLs. - [Sitemap](https://www.cortrophinhcp.com/sitemap): Full site navigation index. - [Prescribing Information (PDF)](https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-prescribing-information.pdf): Full FDA-approved prescribing information. - [Dosing Guide (PDF)](https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-dosing-guide.pdf): Quick-reference dosing guide for all indications. - [Optimized Enrollment Form (PDF)](https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-optimized-enrollment-form.pdf): Patient enrollment form for the Cortrophin In Your Corner program. - [Gout Billing & Coding Guide (PDF)](https://www.cortrophinhcp.com/pdfs/gout-1-mL-vial-billing-and-coding-guide.pdf): Billing and coding guide for acute gouty arthritis indication.