# Purified Cortrophin(R) Gel (repository corticotropin injection USP) - US Healthcare Professional Site

> Official U.S. website for healthcare professionals for Purified Cortrophin(R) Gel
> (repository corticotropin injection USP), a prescription injectable adrenocorticotropic
> hormone (ACTH) product from ANI Pharmaceuticals, Inc. Provides Prescribing Information,
> Important Safety Information, approved indications, proposed mechanism of action, dosing
> and administration, prescribing and enrollment resources, and reimbursement and patient
> access support. Intended for U.S. healthcare professionals only. See the full Prescribing
> Information for complete details, including indications, contraindications, warnings, and
> adverse reactions.

Manufacturer: ANI Pharmaceuticals, Inc.
HCP website: https://www.cortrophinhcp.com
Patient/Caregiver website: https://www.cortrophin.com
Prescribing Information (PDF): https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-prescribing-information.pdf
Medical Information: 1-800-434-1121
Adverse Event Reporting: 1-800-308-6755, or FDA MedWatch at 1-800-FDA-1088 / www.fda.gov/medwatch
Last updated: 2026-07

## Prescribing & Safety
- [Full Prescribing Information (PDF)](https://www.cortrophinhcp.com/pdfs/purified-cortrophin-gel-prescribing-information.pdf): FDA-approved Prescribing Information, including indications and usage, contraindications, warnings and precautions, and adverse reactions.
- [About Cortrophin Gel & Dosing](https://www.cortrophinhcp.com/about-cortrophin-gel-and-dosing): Dosing, storage, and administration information. Supplied as a multi-dose vial and a single-dose prefilled syringe (PFS); refrigerate at 36-46F (2-8C). Important Safety Information is presented on-page.

## Product & Clinical
- [Proposed Mechanism of Action of ACTH](https://www.cortrophinhcp.com/proposed-moa-of-acth): Overview of the proposed adrenal-dependent and adrenal-independent mechanisms of action of natural-sequence ACTH (1-39) and its proposed interactions with melanocortin receptors.

## Approved Indications
- [Acute Gouty Arthritis Flares](https://www.cortrophinhcp.com/acute-gouty-arthritis-flares): Approved indication information for short-term adjunctive therapy during an acute episode or exacerbation of acute gouty arthritis.
- [Rheumatoid Arthritis Flares](https://www.cortrophinhcp.com/rheumatoid-arthritis-flares): Approved indication information for rheumatoid arthritis, including juvenile rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
- [Atopic Dermatitis](https://www.cortrophinhcp.com/atopic-dermatitis): Approved indication information for atopic dermatitis.
- [Severe Psoriasis](https://www.cortrophinhcp.com/severe-psoriasis): Approved indication information for severe psoriasis and severe erythema multiforme (Stevens-Johnson syndrome).
- [Select Cases of Systemic Lupus Erythematosus (SLE)](https://www.cortrophinhcp.com/select-cases-of-sle): Approved indication information for exacerbations or maintenance therapy in select cases of SLE.
- [Select Cases of Dermatomyositis / Polymyositis (DM-PM)](https://www.cortrophinhcp.com/select-cases-of-dm-pm): Approved indication information for exacerbations or maintenance therapy in select cases of systemic dermatomyositis (polymyositis).
- [Symptomatic Sarcoidosis](https://www.cortrophinhcp.com/symptomatic-sarcoidosis): Approved indication information for symptomatic sarcoidosis.
- [Multiple Sclerosis Flares](https://www.cortrophinhcp.com/multiple-sclerosis-flares): Approved indication information for the treatment of acute exacerbations of multiple sclerosis in adults.
- [Proteinuria - Nephrotic Syndrome (FSGS)](https://www.cortrophinhcp.com/proteinuria-due-to-certain-types-of-ns-fsgs): Approved indication information for inducing diuresis or remission of proteinuria in nephrotic syndrome without uremia - focal segmental glomerulosclerosis (FSGS).
- [Proteinuria - Nephrotic Syndrome (MN)](https://www.cortrophinhcp.com/proteinuria-due-to-certain-types-of-ns-mn): Approved indication information for inducing diuresis or remission of proteinuria in nephrotic syndrome without uremia - membranous nephropathy (MN).
- [Severe Inflammatory Ophthalmic Diseases](https://www.cortrophinhcp.com/severe-inflammatory-ophthalmic-diseases): Approved indication information for severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa.

## Access & Support
- [Prescribe & Enroll](https://www.cortrophinhcp.com/prescribe-and-enroll): Prescribing and enrollment steps for HCPs, including enrollment forms and the Cortrophin In Your Corner (CIYC) patient access program.
- [Reimbursement & Support](https://www.cortrophinhcp.com/reimbursement-support): Coverage, reimbursement, and patient access support through Cortrophin In Your Corner, including benefits investigation, prior authorization assistance, copay support for eligible commercially insured patients, and patient assistance for eligible uninsured patients.
- [Resources](https://www.cortrophinhcp.com/resources): Downloadable HCP and patient materials, including dosing guide, enrollment forms, injection guides, billing and coding guides, MAC flashcards, and condition-specific patient brochures (English and Spanish).

## Patient Site
- [Cortrophin Gel Patient & Caregiver Site](https://www.cortrophin.com): Official U.S. patient and caregiver website for Purified Cortrophin Gel.